Immune System and Cannabidiol (CBD) How Does It Work?

After the pandemic, many people have been rightfully concerned for their overall health and immune systems. More and more people started to do at-home exercises and built habits to maintain healthy bodies.

Supplements are another way that you can boost your health. Many natural supplements are available on the market today, including one CBD. Although CBD has gained much attention for its calming effects, it has many other applications.

Curious about how CBD can benefit your immune system? Learn more about how it works below!

About CBD

The Cannabis sativa plant contains more than 80 compounds, also called cannabinoids.

A non-psychoactive substance called CBD is obtained from hemp or cannabis plants. Cannabidiol, or CBD, is a relative of its famous psychoactive counterpart, THC.

The Immune System

We are exposed to a constant stream of illnesses, infections, viruses, and bacteria daily. An internal defense mechanism in our bodies keeps invaders at bay. 

Our immune systems, which comprise a network of cells, organs, and tissues that collaborate to do this, keep us healthy and alive by eradicating these foreign cells or particles. 

The immune system is also responsible for identifying malfunctioning cells and removing them from the body. Your immune system must remove these cells to prevent them from increasing and developing into tumors.

One of the gatekeepers of the immune system, the endocannabinoid system, is thought to have significant effects on the neurological system and regulate immunity. 

Endocannabinoid System

They are known as the endocannabinoid system is a dynamic and intricate cell signaling network. Endocannabinoids, enzymes, and cannabinoid receptors regulate several different biological functions.

The body naturally makes its cannabinoids called endocannabinoids. Brain, muscle, and blood vessel cells are just some places you’ll find them.

When endocannabinoids attach to cannabinoid receptors found all over the body, they become active. 

CBD’s Interaction With The Immune System

Interaction With Endocannabinoid System

A practical and balanced immune system may be maintained by CBD, a phytocannabinoid that operates on the endocannabinoid system.

Many think CBD functions by stopping the breakdown of endocannabinoids. As a result, they can affect your body more. Some people believe that CBD binds to an unidentified receptor.

The transient receptor potential vanilloid 2 (TRPV2) protein is critical for proper cell-to-cell communication, which is vital for a healthy functioning immune system.

CBD activates TRPV2, and it also affects other TRP channels that are involved in promoting immunity.

What experts do know about CBD is that CBD may assist with pain, nausea, and other symptoms linked to a variety of diseases. However, the specifics of how it works are still up for debate.

How CBD Strengthens Immune System

Better Inflammatory Response

CBD also contains anti-inflammatory qualities that can suppress and modulate immune responses and assist in lowering the inflammatory response of your immune system.

This aids in the isolation of contaminated areas and stops the toxic elements from spreading to other places in your body. CBD contains anti-inflammatory components 

Calming Effect

Immune system deterioration is connected to ongoing psychological stress. Stress can be reduced, and the user can experience relaxing benefits thanks to CBD.

CBD supplementation directly activates the 5-HT1A serotonin receptor, as opposed to natural cannabinoids, which operate on the CB1 receptor.

The ability of CBD to control cerebral blood flow in brain areas associated with anxiety, such as the amygdala, hippocampus, hypothalamus, and cingulate cortex, is likewise linked to its ability to reduce stress.

Maintain a Healthy Gut

A significant percentage of the immune system is found in the GI tract. The collection of excellent and harmful microorganisms known as the gut microbiota is located in the intestines.

Intestinal permeability, gut microbiota dysbiosis, and a compromised intestinal immune response can all be caused by excessive gut inflammation. The endocannabinoid system is one method the body combats.

Increase Activity of Natural Killer Cells

The body’s reaction to the presence of viruses is significantly influenced by NK cells.

It has been demonstrated that hemp-derived CBD oil regulates immunological function by lowering T cell, B cell, T helper, and T cytotoxic lymphocyte subset activity.

Outside of an autoimmune setting, however, CBD promotes the activity of natural killer T cells, which possess traits common to both NK and T cells.

CBD Compared To Other Supplements For Your Immune System

Traditional immunosuppressive and synthetically made drugs are used to treat autoimmune diseases. Unfortunately, these medications make people more prone to illness and infection since they suppress the immune system’s overactive response.

However, CBD may be able to control those autoimmune disorders by merely suppressing a portion of the immune system.

Due to its tendency to suppress the immune system, CBD may benefit individuals whose immune systems are overactive or compromised.

CBD Can Aid In Overall Wellness Through Prevention

Genetic flaws are the underlying cause of primary immunological illnesses such as B cell (antibody) deficits, T cell deficiencies, and combined B and T cell deficiencies. These conditions cannot be prevented.

Nevertheless, there are specific measures to stop infections in those with reduced immune systems, such as controlling stress and getting enough sleep.

The immune system’s reactions are weakened by stress, while social support and relaxation improve health.

CBD oil’s anxiolytic (anti-anxiety) properties, on the other hand, have shown promise for alleviating stress and easing anxiety.

Studies have also suggested that various essential oils, particularly eucalyptus and ginger, may improve immunological function.

How You Can Incorporate CBD Into Your Life

Oil and tinctures are the best options for pain treatment, mental clarity, and stress reduction. The administration quickly and effectively reaches the bloodstream. 

For those who want their CBD to taste delicious, edibles, beverages, and gummies are fantastic options. Edibles are typically precisely dosed for the customer, so you can choose the amount you need for your needs and conditions.

CBD capsules are a fantastic alternative for anyone who wants the advantages of CBD without the aftertaste and quick activation.

CBD can be taken through vaporizer pens. This technique is an excellent substitute for smoking since it offers prompt relief.

You may easily find CBD products online from different suppliers. To know where to purchase CBD products, look for a supplier that has done third-party testing, has a reputable name, and has good reviews from other customers.


Overall, CBD, the compound of the Cannabis Sativa plant that does not produce a “high,” may be beneficial to strengthening the immune system.

The immune system serves as the internal defense mechanism in our bodies. CBD boosts this system by aiding the endocannabinoid system, which plays a part in controlling bodily processes.

CBD helps stop the breakdown of endocannabinoids maintaining a balanced immune system.

CBD can improve the immune system by lowering the inflammatory response, preventing immune system deterioration related to stress, maintaining a healthy gut, and increasing the activity of natural killer cells.